By Andreas Stahl
This ebook offers a concise assessment over the pathology of retinal angiogenic illnesses and explains why anti-angiogenic treatment is valuable in such a lot of sufferers. The reader is guided in the course of the a number of medical symptoms for anti-angiogenic remedy and made conscious of its benefits in addition to present demanding situations and barriers. it's defined how, considering the fact that its advent for the remedy of exudative age-related macular degeneration in 2006, anti-angiogenic treatment has revolutionized the way we deal with a variety of ocular ailments. the entire authors are tested specialists of their respective fields who percentage their large wisdom and medical adventure with the reader. This e-book is either a worthy creation to anti-angiogenic remedy in ophthalmology and a daily better half for all ophthalmologists seeing sufferers with probably the most standard retinal diseases.
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Extra info for Anti-Angiogenic Therapy in Ophthalmology
1016/j. 014. e1111S0002-9394(13)00070-6 [pii]. Hellstrom A, Perruzzi C, Ju M, Engstrom E, Hard AL, Liu JL, Albertsson-Wikland K, Carlsson B, Niklasson A, Sjodell L, LeRoith D, Senger DR, Smith LE. Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: direct correlation with clinical retinopathy of prematurity. Proc Natl Acad Sci U S A. 2001;98(10):5804–8. 101113998. 101113998 [pii]. Hellstrom A, Carlsson B, Niklasson A, Segnestam K, Boguszewski M, de Lacerda L, Savage M, Svensson E, Smith L, Weinberger D, Albertsson Wikland K, Laron Z.
In addition, IGF-1 is also an important inducer of overall growth and development of all tissues (Netchine et al. 2011). The role of IGF-1 in ROP may therefore be twofold: First, IGF-1 may directly promote normal retinal development during Phase I of ROP when vascular growth in the retina is stalled. Augmented retinal vascular growth during Phase I in turn would lead to a reduced size of peripheral avascular retina in later weeks of life and would therefore limit overexpression of angiogenic growth factors, thereby preventing or curtailing Phase II.
Oxygen targets for preterm infants. Neonatology. 2013;103(4):341–5. 1159/ 000349936. 000349936 [pii]. Terry TL. Retrolental fibroplasia in the premature infant: V. Further studies on fibroblastic overgrowth of the 2 Retinopathy of Prematurity persistent tunica vasculosa lentis. Trans Am Ophthalmol Soc. 1944;42:383–96. Velez-Montoya R, Clapp C, Rivera JC, Garcia-Aguirre G, Morales-Canton V, Fromow-Guerra J, GuerreroNaranjo JL, Quiroz-Mercado H. Intraocular and systemic levels of vascular endothelial growth factor in advanced cases of retinopathy of prematurity.